ASCLS eNewsBytes

• Kidney and liver transplants less common in patients with HIV September 3, 2024
  Low rates of kidney and liver transplantation occur among HIV-positive individuals, despite comparable post-operative outcomes. Expanding access to deceased and living donor kidney allografts and addressing ESKD or ESLD is needed.
• Emergent Bio's smallpox vaccine gets US approval for mpox September 3, 2024
  The U.S. FDA has approved Emergent BioSolutions' new tab smallpox vaccine, making it the second approved shot against mpox in the U.S.. The vaccine, ACAM2000, uses a live, infectious form of the vaccinia virus, but cannot be administered to those with weakened immune systems.
• Tiny test tubes sort stem cells for improved therapy September 3, 2024
  Researchers at the University of California, Los Angeles, have developed a method to identify subpopulations of mesenchymal stem cells secreting high levels of extracellular vesicles, potentially allowing for the selection of more therapeutically active cells for clinical applications.
• Insect illnesses spike around the world September 3, 2024
  The spread of rare insect-borne diseases like eastern equine encephalitis and Oropouche fever is increasing due to global warming, longer, hotter summers and changes in land use. This has led to increased risks of dengue fever, West Nile Virus and malaria.
• Inhibition of miR-10b treats metastatic breast cancer by targeting stem cell-like properties September 3, 2024
  The study presents a nanodrug, MN-anti-miR10b, which inhibits miR-10b, a key driver of metastatic breast cancer, and has shown to prevent metastasis and eliminate existing metastases in mice models, making it an effective treatment option for stem-like breast cancer.